UCD Post-doctoral Research Fellow Level 1, UCD School of Biomolecular and Biomedical Science, 011165
Job Ref : 011165
This is a research focused role, where you will conduct a specified programme of research supported by research training and development under the supervision and direction of a Principal Investigator.
The primary purpose of the role is to further develop your research skills and competences, including the processes of publication in peer-reviewed academic publications, the development of funding proposals, the mentorship of graduate students along with the opportunity to develop your skills in research led teaching.
A 1-year postdoctoral position funded by Enterprise Ireland through the Commercialisation Fund programme is available to develop a powerful protein degradation technology. The projected programme will put into development a powerful platform protease technology that will reduce contamination risk for the healthcare/hospital/clinical sector with an aim to spinout. The technology has been developed and championed by the leading Prion expert in Ireland (Dr. Hilary McMahon) and it degrades the most difficult to degrade protein, the prion, under mild conditions. The prion is the agent that causes the fatal disorder variant Creutzfeldt-Jakob disease (vCJD), which originated from Bovine Spongiform Encephalopathy (BSE) contaminated products. We now have asymptomatic vCJD carriers. At least 1 in 2000 persons are vCJD carriers, we do not know who they are, and they have the potential to transmit the infectious disease agent through hospital procedures via contaminated surgical equipment, including endoscopes, used in hospital procedures. The prion sticks like glue to surgical equipment, and it cannot be removed by standard cleaning practises used in hospitals. This leads to a persistent CJD contamination transmission risk in the hospital sector which can be overcome with this technology.
This disruptive technology is based on a rare microbial protease technology, and it will be evolved during this current phase of the work programme. The work merges microbial enzyme production with the destruction of the infectious risk of the neurological Prion.
Principal Duties and Responsibilities
- Conduct a specified programme of research and scholarship under the supervision and direction of your Principal Investigator;
- Engage in appropriate training and professional development opportunities as required by your Principal Investigator, your School or Institute, or the University;
- Engage in the dissemination of the results of the research in which you are engaged as directed by and with the support of and under the supervision of your Principal Investigator;
- Engage in the wider research and scholarly activities of your research group, School and Institute;
- Mentor and assist, as appropriate and as directed, the research graduate students in your group, School and Institute;
- Carry out administrative work associated with your programme of research.
Selection criteria outline the qualifications, skills, knowledge and/or experience that the successful candidate would need to demonstrate for successful discharge of the responsibilities of the post.
Applications will be assessed on the basis of how well candidates satisfy these criteria.
- PhD in Microbiology, Biochemistry or Molecular biology;
- Experience with microbial fermentation for protein expression;
- Molecular biology experience;
- A demonstrated commitment to research and publications;
- An understanding of the operational requirements for a successful research project;
- Evidence of research activity (publications, conference presentations, awards) and future scholarly output (working papers, research proposals, and ability to outline a research project;
- Excellent Communication Skills (Oral, Written , Presentation etc.);
- Excellent Organisational and Administrative skills including a proven ability to work to deadlines.
The PD1 position is intended for early stage researchers, either just after completion of a PhD or for someone entering a new area for the first time. If you have already completed your PD1 stage in UCD or will soon complete a PD1, or you are an external applicant whose total Postdoctoral experience, inclusive of the duration of the advertised post, would exceed 4 years, you should not apply and should refer to PD2 posts instead.
- Post-Doctoral Research Experience;
- Experience with cell culture technology and protein detection technology;
- Experience with scale up of microbial fermentations;
- Experience in enzyme research;
- Experience in setting own research agenda.